Reaction Details Report a problem with these data
Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM552685
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) VHL Binding Assay
IC50
80±n/a nM
Citation
 Jakob, F; Hao, W; J., FW 1-(2-(4-CYCLOPROPYL-1H-1,2,3-TRIAZOL-1-YL)ACETYL)-4-HYDROXY-N-(BENZYL)PYRROLIDIN E-2-CARBOXAMIDE DERIVATIVES AS VHL INHIBITORS FOR THE TREATMENT OF ANEMIA AND CANCER WIPO 0:0 (2022) [PubMed] 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Homo sapiens (Human)
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM552685
Synonyms:
(2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-oxopropan-2-yl)-l-((S)-2-(4-((2-acetamidoethoxy)methyl)-lH-l,2,3-triazol-I-yl)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide ( Compound 14) | WO2022103411, Example S14
Type:
Small organic molecule
Emp. Form.:
C33H43N7O6
Mol. Mass.:
633.7378
SMILES:
CC(=O)NCCOCc1cn(nn1)[C@H](C(=O)N1C[C@H](O)CC1C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O)C(C)(C)C |r|
Structure:
Search PDB for entries with ligand similarity: