Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase BTK
Ligand
BDBM174578
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
Temperature
298.15±n/a K
IC50
4.90±n/a nM
Comments
extracted
Citation
 Owens, TD Tyrosine kinase inhibitors US Patent  US9688676 Publication Date 6/27/2017 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM174578
Synonyms:
US9688676, 27 (R)-2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)piperidine-1-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile
Type:
Small organic molecule
Emp. Form.:
C37H41FN8O4
Mol. Mass.:
680.771
SMILES:
CC(C)(C=C(C#N)C(=O)N1CCC[C@H](C1)n1c2ccnc(N)c2n(-c2ccc(Oc3ccccc3)cc2F)c1=O)N1CCN(CC1)C1COC1 |r,w:3.2,wD:13.15,(-3.81,-5.57,;-4.96,-6.6,;-6.1,-7.63,;-3.93,-7.74,;-2.42,-7.42,;-1.39,-8.57,;-.36,-9.71,;-1.94,-5.96,;-2.97,-4.81,;-.44,-5.64,;.59,-6.78,;2.1,-6.46,;2.58,-5,;1.54,-3.85,;.04,-4.17,;2.02,-2.39,;3.49,-1.91,;4.82,-2.68,;6.15,-1.91,;6.15,-.37,;4.82,.4,;4.82,1.94,;3.49,-.37,;2.02,.11,;1.54,1.57,;2.58,2.71,;2.1,4.18,;.59,4.5,;.12,5.96,;1.15,7.11,;.67,8.57,;1.7,9.72,;3.21,9.4,;3.68,7.93,;2.65,6.79,;-.44,3.35,;.04,1.89,;-.99,.75,;1.12,-1.14,;-.42,-1.14,;-5.99,-5.45,;-7.49,-5.77,;-8.52,-4.63,;-8.05,-3.16,;-6.54,-2.84,;-5.51,-3.99,;-9.08,-2.02,;-10.62,-1.94,;-10.54,-.4,;-9,-.48,)|
Structure:
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