Reaction Details Report a problem with these data
Target
Epidermal growth factor receptor [696-1022,L858R]
Ligand
BDBM554457
Substrate
n/a
Meas. Tech.
Kinase Hotspot Assay
IC50
7.83±n/a nM
Citation
 Mahmoud, GE; Choi, HS; Yoo, KH; Han, DK; Oh, CH; Mohammed, A; Mohammed, IE; Ammar, UM Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same US Patent  US11332479 Publication Date 5/17/2022 
Target
Name:
Epidermal growth factor receptor [696-1022,L858R]
Synonyms:
EGF-R Tyrosine Kinase Mutant (L858R) | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor [696-1022,L858R] | HER1 | c-raf
Type:
Tyrosine-protein kinase
Mol. Mass.:
37296.75
Organism:
Homo sapiens (Human)
Description:
P00533[696-1022,L858R]
Residue:
327
Sequence:
GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG
  
Inhibitor
Name:
BDBM554457
Synonyms:
US11332479, Compound 31II
Type:
Small organic molecule
Emp. Form.:
C21H22FN7O3S2
Mol. Mass.:
503.573
SMILES:
CCN1CCN(CCNc2nccc(n2)-c2c(nc3sccn23)-c2ccc(F)c(O)c2)S1(=O)=O
Structure:
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