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Target
Epidermal growth factor receptor [696-1022,L858R]
Ligand
BDBM50396483
Substrate
n/a
Meas. Tech.
Kinase Hotspot Assay
IC50
48.0±n/a nM
Citation
 Mahmoud, GE; Choi, HS; Yoo, KH; Han, DK; Oh, CH; Mohammed, A; Mohammed, IE; Ammar, UM Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same US Patent  US11332479 Publication Date 5/17/2022 
Target
Name:
Epidermal growth factor receptor [696-1022,L858R]
Synonyms:
EGF-R Tyrosine Kinase Mutant (L858R) | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor [696-1022,L858R] | HER1 | c-raf
Type:
Tyrosine-protein kinase
Mol. Mass.:
37296.75
Organism:
Homo sapiens (Human)
Description:
P00533[696-1022,L858R]
Residue:
327
Sequence:
GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG
  
Inhibitor
Name:
BDBM50396483
Synonyms:
PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemurafenib | US11332479, Compound Vemurafenib | US11492357, Control | US9388165, Reference, Vemurafenib (PLX-4032) | USRE47451, PLX-4032, Roche | VEMURAFENIB
Type:
Small organic molecule
Emp. Form.:
C23H18ClF2N3O3S
Mol. Mass.:
489.922
SMILES:
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Structure:
Search PDB for entries with ligand similarity: