Reaction Details Report a problem with these data
Target
Sodium/glucose cotransporter 2
Ligand
BDBM555244
Substrate
n/a
Meas. Tech.
Inhibitory Effect on the Sodium-dependent Glucose Co-Transporter SGLT, SGLT1 and SGLT2
IC50
18.0±n/a nM
Citation
 Bebernitz, GR; Bock, MG; Reddy, DS; Hajare, AK; Vyavahare, V; Bhosale, SB; Kurhade, SE; Salunkhe, V; Shaikh, NS; Bhuniya, D; Palle, PV; Feng, L; Liang, J Glycoside derivatives and uses thereof US Patent  USRE49080 Publication Date 5/24/2022 
Target
Name:
Sodium/glucose cotransporter 2
Synonyms:
Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2
Type:
Protein
Mol. Mass.:
72902.00
Organism:
Homo sapiens (Human)
Description:
P31639
Residue:
672
Sequence:
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA
  
Inhibitor
Name:
BDBM555244
Synonyms:
USRE49080, Example 10
Type:
Small organic molecule
Emp. Form.:
C25H30ClNO6
Mol. Mass.:
475.962
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc3OCCN(CC4CC4)c3c2)c1 |r|
Structure:
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