Reaction Details Report a problem with these data
Target
TGF-beta receptor type-2
Ligand
BDBM283013
Substrate
n/a
IC50
7197±n/a nM
Citation
 Kinsella, T; Gelman, M; Hong, H; Darwish, IS; Singh, R; Yu, J; Borzilleri, RM; Velaparthi, U; Liu, P; Dame, CP; Rahaman, H; Warrier, JS TGF-beta inhibitors US Patent  US11352360 Publication Date 6/7/2022 
Target
Name:
TGF-beta receptor type-2
Synonyms:
TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
64559.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586859
Residue:
567
Sequence:
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
  
Inhibitor
Name:
BDBM283013
Synonyms:
6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- imidazol-5-yl)-3-(difluoromethyl) imidazo[1,2-b]pyridazine | US10287295, Example 215' | US11352360, Example 215' | US9884868, Example 215'
Type:
Small organic molecule
Emp. Form.:
C18H12F5N5
Mol. Mass.:
393.3134
SMILES:
FC(F)Cn1cnc(c1-c1ccc2ncc(C(F)F)n2n1)-c1ccc(F)cc1
Structure:
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