Reaction Details Report a problem with these data
Target
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Ligand
BDBM557750
Substrate
n/a
Meas. Tech.
Cell Free Mcl-1: Bim Affinity Assay (Mcl-1 HTRF)
IC50
0.340±n/a nM
Citation
 Brown, SP; Li, K; Li, Y; Reed, AB; Lanman, BA Compounds that inhibit Mcl-1 protein US Patent  US11364248 Publication Date 6/21/2022 
Target
Name:
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]/Bcl-2-like protein 11 [51-76] | Mcl-1 and BIM | Mcl-1/BIM
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17896.13
Organism:
Homo sapiens (Human)
Description:
Q07820[171-327]
Residue:
157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
  
Component 2
Name:
Bcl-2-like protein 11 [51-76]
Synonyms:
B2L11_HUMAN | BCL2L11 | BIM | Bcl-2-like protein 11 (51-76) | Bcl-2-like protein 11 (BIM) (51-76)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
2530.22
Organism:
Homo sapiens (Human)
Description:
O43521[51-76]
Residue:
26
Sequence:
EGDSCPHGSPQGPLAPPASPGPFATR
  
Inhibitor
Name:
BDBM557750
Synonyms:
US11364248, Example 46
Type:
Small organic molecule
Emp. Form.:
C39H54ClN3O6S
Mol. Mass.:
728.381
SMILES:
CCN(C)[C@H]1CO[C@H](OC1)[C@H]1CCC[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,wU:10.10,47.49,44.47,14.15,16.17,7.6,4.3,wD:30.31,(-32.45,-15.02,;-31.11,-14.25,;-29.78,-15.02,;-28.45,-14.25,;-29.78,-16.56,;-28.45,-17.33,;-28.45,-18.87,;-29.78,-19.64,;-31.11,-18.87,;-31.11,-17.33,;-29.78,-21.18,;-28.45,-21.95,;-27.11,-21.18,;-25.78,-21.95,;-25.78,-23.49,;-24.44,-22.72,;-24.44,-24.26,;-23.11,-23.49,;-24.44,-25.8,;-23.11,-25.03,;-24.05,-27.29,;-26.13,-26.8,;-27.47,-26.03,;-27.47,-24.49,;-28.58,-26.76,;-28.58,-28.3,;-29.91,-29.07,;-31.24,-28.3,;-32.45,-29.26,;-33.95,-28.92,;-34.62,-27.53,;-35.39,-28.87,;-36.93,-28.87,;-37.7,-27.53,;-36.93,-26.2,;-37.7,-24.87,;-36.93,-23.53,;-37.7,-22.2,;-35.39,-23.53,;-34.62,-24.87,;-35.39,-26.2,;-33.95,-26.15,;-32.45,-25.8,;-32.45,-24.26,;-31.11,-23.49,;-29.78,-24.26,;-29.78,-22.72,;-31.11,-21.95,;-31.24,-26.76,;-29.91,-25.99,)|
Structure:
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