Reaction Details Report a problem with these data
Target
Epidermal growth factor receptor [1-772,'NPH',773-1210]
Ligand
BDBM557858
Substrate
n/a
Meas. Tech.
Cell Viability Assay and IC50 Estimation
IC50
15.0±n/a nM
Citation
Heymach, J; Robichaux, J; Nilsson, M; Jones, P; Cross, J; Theroff, J Heterocyclic inhibitors of tyrosine kinase US Patent US11365189 Publication Date 6/21/2022
More Info.:
Target
Name:
Epidermal growth factor receptor [1-772,'NPH',773-1210]
Synonyms:
EGFR | EGFR_HUMAN | ERBB | ERBB1 | HER1 | h773insnph
Type:
Enzyme Catalytic Domain
Mol. Mass.:
134628.45
Organism:
Homo sapiens (Human)
Description:
P00533[1-772,'NPH',773-1210]
Residue:
1213
Sequence:
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPNPHHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
Inhibitor
Name:
BDBM557858
Synonyms:
6-((1-acryloylpiperidin-4- yl)oxy)-4-((4-bromo-3- chlorophenyl)amino)-7- methoxyquinoline-3- carbonitrile | US11365189, Ex. No. 14
Type:
Small organic molecule
Emp. Form.:
C25H22BrClN4O3
Mol. Mass.:
541.824
SMILES:
COc1cc2ncc(C#N)c(Nc3ccc(Br)c(Cl)c3)c2cc1OC1CCN(CC1)C(=O)C=C