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Target
Cytochrome P450 4F2
Ligand
BDBM558216
Substrate
n/a
Meas. Tech.
Inhibition Test for Each Compound of the Present Invention Against 20-HETE Producing Enzymes (CYP4F2 and CYP4A11)
IC50
7.30±n/a nM
Citation
 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K Pyridine compound substituted with azole US Patent  US11365192 Publication Date 6/21/2022 
Target
Name:
Cytochrome P450 4F2
Synonyms:
20-HETE synthase | 20-hydroxyeicosatetraenoic acid synthase | Arachidonic acid omega-hydroxylase | CP4F2_HUMAN | CYP4F2 | CYPIVF2 | Cytochrome P450 4F2 | Cytochrome P450-LTB-omega | Leukotriene-B(4) 20-monooxygenase 1 | Leukotriene-B(4) omega-hydroxylase 1 | Phylloquinone omega-hydroxylase CYP4F2
Type:
PROTEIN
Mol. Mass.:
59859.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_10743
Residue:
520
Sequence:
MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
  
Inhibitor
Name:
BDBM558216
Synonyms:
US11365192, Example 11-3
Type:
Small organic molecule
Emp. Form.:
C10H10BrClO2
Mol. Mass.:
277.542
SMILES:
CCOC(=O)c1cc(CBr)ccc1Cl
Structure:
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