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Target
Arginase-2, mitochondrial
Ligand
BDBM290423
Substrate
n/a
IC50
125±n/a nM
Citation
 Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent  US11389464 Publication Date 7/19/2022 
Target
Name:
Arginase-2, mitochondrial
Synonyms:
ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase
Type:
PROTEIN
Mol. Mass.:
38576.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978892
Residue:
354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
  
Inhibitor
Name:
BDBM290423
Synonyms:
(3R,4S)-3-amino-4-(3-boronopropyl)-1-((5,7-dichloro-1,2,3,4- tetrahydroisoquinolin-3-yl)methyl)pyrrolidine-3-carboxylic acid | US10098902, Example 59 | US10603330, Example 59 | US11389464, Example 59
Type:
Small organic molecule
Emp. Form.:
C18H26BCl2N3O4
Mol. Mass.:
430.134
SMILES:
N[C@]1(CN(CC2Cc3c(Cl)cc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O |r|
Structure:
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