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Target
Protein cereblon
Ligand
BDBM562164
Substrate
n/a
Meas. Tech.
Fluorescence Direct Binding Protocol
Kd
5.00±n/a nM
Citation
 Norcross, R; Britschgi, A; Dey, F; Goergler, A; Kusznir, EA; Wichert, MA Dihydroquinolinones for medical treatment US Patent  US11401256 Publication Date 8/2/2022 
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM562164
Synonyms:
6-(3,4-Dihydro-2H-quinoline-1-carbonyl)-3,4-dihydro-1H-quinolin-2-one | US11401256, Example 56
Type:
Small organic molecule
Emp. Form.:
C19H18N2O2
Mol. Mass.:
306.3584
SMILES:
O=C(N1CCCc2ccccc12)c1ccc2NC(=O)CCc2c1
Structure:
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