Reaction Details
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Bcl-2-like protein 1/Bcl2-associated agonist of cell death [103-127,M117N]
Ligand
BDBM562371
Substrate
n/a
Meas. Tech.
Protein-Protein Interaction Assay
IC50
18000±n/a nM
Citation
Furst, L; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Wei, G; McCarren, PR; Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Mönning, U; Nowak-Reppel, K Macrocyclic indole derivatives US Patent US11401278 Publication Date 8/2/2022 More Info.:
Target
Name:
Bcl-2-like protein 1/Bcl2-associated agonist of cell death [103-127,M117N]
Synonyms:
BCL-XL/Bad BH3
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Component 2
Name:
Bcl2-associated agonist of cell death [103-127,M117N]
Synonyms:
BAD | BAD_HUMAN | BBC6 | BCL2L8 | cl2-associated agonist of cell death (BAD)(BH3)
Type:
n/a
Mol. Mass.:
3088.39
Organism:
Homo sapiens (Human)
Description:
Q92934[103-127,M117N]
Residue:
25
Sequence:
NLWAAQRYGRELRRNSDEFVDSFKK
Inhibitor
Name:
BDBM562371
Synonyms:
(rac)-2,3,14-trimethyl-15-[2-(rac)-(morpholin-4-yl)ethyl]-7-[3-(1-naphthyloxy)propyl]-11,12,14,15-tetrahydro-2H,10H-pyrazolo[3′,4′:4,5][1,2,8]thiadiazacycloundecino[6,7,8-hi]indole-8-carboxylic acid 13,13-dioxide (Mixture of Stereoisomers) | US11401278, Example 44 | US11401278, Example 45 | US11401278, Example 46
Type:
Small organic molecule
Emp. Form.:
C38H45N5O6S
Mol. Mass.:
699.859
SMILES:
CN1C(CCN2CCOCC2)c2nn(C)c(C)c2-c2cccc3c(CCCOc4cccc5ccccc45)c(C(O)=O)n(CCCS1(=O)=O)c23
Structure:
