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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D7 [S54D]
Ligand
BDBM562449
Substrate
n/a
Meas. Tech.
Kinetic Assay
IC50
<1000±n/a nM
Citation
 Gurney, ME; Hagen, TJ; Mo, X; Vellekoop, AS; Romero, DL; Campbell, R; Walker, JR; Zhu, L Heteroaryl inhibitors of PDE4 US Patent  US11401286 Publication Date 8/2/2022 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D7 [S54D]
Synonyms:
DPDE3 | PDE4D | PDE4D_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
84232.40
Organism:
Homo sapiens (Human)
Description:
Q08499-2[S54D]
Residue:
745
Sequence:
NTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESSGFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRREDFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
  
Inhibitor
Name:
BDBM562449
Synonyms:
3-[4-[[2-(3-Chlorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]amino]phenyl]propanoic acid | US11401286, Example 16
Type:
Small organic molecule
Emp. Form.:
C22H20ClN3O2
Mol. Mass.:
393.866
SMILES:
OC(=O)CCc1ccc(Nc2nc(nc3CCCc23)-c2cccc(Cl)c2)cc1
Structure:
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