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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [S133D]
Ligand
BDBM562554
Substrate
n/a
Meas. Tech.
Kinetic Assay
IC50
>1000±n/a nM
Citation
 Gurney, ME; Hagen, TJ; Mo, X; Vellekoop, AS; Romero, DL; Campbell, R; Walker, JR; Zhu, L Heteroaryl inhibitors of PDE4 US Patent  US11401286 Publication Date 8/2/2022 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [S133D]
Synonyms:
DPDE4 | PDE4B | PDE4B_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
83345.88
Organism:
Homo sapiens (Human)
Description:
Q07343[S133D]
Residue:
736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRREDFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM562554
Synonyms:
2-(4-((2-(3-Chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)methyl)phenyl)-2-methylpropanoic acid hydrochloride | US11401286, Example 126
Type:
Small organic molecule
Emp. Form.:
C25H24ClNO2
Mol. Mass.:
405.917
SMILES:
CC(C)(C(O)=O)c1ccc(Cc2cc(nc3CCCc23)-c2cccc(Cl)c2)cc1
Structure:
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