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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [S133D]
Ligand
BDBM562558
Substrate
n/a
Meas. Tech.
Kinetic Assay
IC50
<1000±n/a nM
Citation
 Gurney, ME; Hagen, TJ; Mo, X; Vellekoop, AS; Romero, DL; Campbell, R; Walker, JR; Zhu, L Heteroaryl inhibitors of PDE4 US Patent  US11401286 Publication Date 8/2/2022 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [S133D]
Synonyms:
DPDE4 | PDE4B | PDE4B_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
83345.88
Organism:
Homo sapiens (Human)
Description:
Q07343[S133D]
Residue:
736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRREDFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM562558
Synonyms:
4-(4-((2-(3-Chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)phenyl)butanamide hydrochloride | US11401286, Example 130
Type:
Small organic molecule
Emp. Form.:
C24H24ClN3O
Mol. Mass.:
405.92
SMILES:
NC(=O)CCCc1ccc(Nc2cc(nc3CCCc23)-c2cccc(Cl)c2)cc1
Structure:
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