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Target
Isoform 7 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Ligand
BDBM50524994
Substrate
n/a
Meas. Tech.
Kinetic Assay
IC50
>1000±n/a nM
Citation
 Gurney, ME; Hagen, TJ; Mo, X; Vellekoop, AS; Romero, DL; Campbell, R; Walker, JR; Zhu, L Heteroaryl inhibitors of PDE4 US Patent  US11401286 Publication Date 8/2/2022 
Target
Name:
Isoform 7 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:
DPDE3 | PDE4D | PDE4D_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
84622.96
Organism:
Homo sapiens (Human)
Description:
Q08499-11
Residue:
748
Sequence:
MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESSGFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
  
Inhibitor
Name:
BDBM50524994
Synonyms:
CHEMBL4541964 | US11401286, Example 142
Type:
Small organic molecule
Emp. Form.:
C21H15ClF3NO2
Mol. Mass.:
405.798
SMILES:
OC(=O)Cc1ccc(Cc2cc(nc(c2)C(F)(F)F)-c2cccc(Cl)c2)cc1
Structure:
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