Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [140-379]
Ligand
BDBM562468
Substrate
n/a
Meas. Tech.
In Vitro Binding Assay
IC50
2810±n/a nM
Citation
 Guo, S; Peng, J; Liu, Y; Guo, H Cyclic dinucleotide compound and uses thereof US Patent  US11401295 Publication Date 8/2/2022 
Target
Name:
Stimulator of interferon genes protein [140-379]
Synonyms:
ERIS | MITA | STING | STING1 | STING_HUMAN | Stimulator of interferon genes protein (STING1)(140-379) | TMEM173
Type:
Enzyme Catalytic Domain
Mol. Mass.:
26958.07
Organism:
Homo sapiens (Human)
Description:
Q86WV6[140-379]
Residue:
240
Sequence:
APAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM562468
Synonyms:
US11401295, Compound 5A
Type:
Small organic molecule
Emp. Form.:
C21H25B2FN10O9P2
Mol. Mass.:
664.053
SMILES:
B[P@@]1(=O)OC[C@H]2O[C@H]([C@@H](F)C2O[P@](B)(=O)OC[C@@]23COC([C@@H](O2)n2cnc4c(N)ncnc24)[C@H]3O1)n1cnc2c(N)ncnc12 |r,THB:23:21:33:18.19|
Structure:
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