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Target
E3 ubiquitin-protein ligase Mdm2 [1-188]
Ligand
BDBM50432652
Substrate
n/a
Meas. Tech.
Homogenous Time-Resolved Fluorescence Assay (HTRF1 Assay)
IC50
1000±n/a nM
Citation
 Bartberger, MD; Beck, HP; Degraffenreid, MR; Fox, BM; Gonzalez Lopez De Turiso, F; Julian, LD; Kayser, F; Medina, JC; Olson, SH; Rew, Y; Roveto, PM; Sun, D; Yan, X CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer US Patent  US11407721 Publication Date 8/9/2022 
Target
Name:
E3 ubiquitin-protein ligase Mdm2 [1-188]
Synonyms:
E3 ubiquitin-protein ligase Mdm2 (aa 1-188) | MDM2 | MDM2_HUMAN
Type:
n/a
Mol. Mass.:
21319.18
Organism:
Homo sapiens (Human)
Description:
Q00987[1-188]
Residue:
188
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDS
  
Inhibitor
Name:
BDBM50432652
Synonyms:
CHEMBL2347393 | US11407721, Example 79
Type:
Small organic molecule
Emp. Form.:
C22H23Cl2NO5
Mol. Mass.:
452.328
SMILES:
CC[C@@H](CO)N1[C@@H]([C@@H](O[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r|
Structure:
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