Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 9 [133-239]
Ligand
BDBM565260
Substrate
n/a
Meas. Tech.
Bromodomain TR-FRET Competition Binding Assay
IC50
<10±n/a nM
Citation
 Ruppel, SK; Yang, Z; Lowe, JT; Voigt, JH; Netherton, M Compounds and uses thereof US Patent  US11414416 Publication Date 8/16/2022 
Target
Name:
Bromodomain-containing protein 9 [133-239]
Synonyms:
BRD9 | BRD9_HUMAN | Bromodomain-containing protein 9 (BRD9)(133-239)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12383.34
Organism:
Homo sapiens (Human)
Description:
aa 133-239
Residue:
107
Sequence:
PAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSK
  
Inhibitor
Name:
BDBM565260
Synonyms:
4-(2-[1-[2-([[2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)phenyl]methyl](methyl)amino)acetyl]-[4,4-bipiperidin]-1-yl]-2-oxoethoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | US11414416, Compound D2 | US11560381, Compound D2
Type:
Small organic molecule
Emp. Form.:
C46H51N7O10
Mol. Mass.:
861.938
SMILES:
COc1cc(cc(OC)c1CN(C)CC(=O)N1CCC(CC1)C1CCN(CC1)C(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)-c1cn(C)c(=O)c2cnccc12
Structure:
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