Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 9 [133-239]
Ligand
BDBM565296
Substrate
n/a
Meas. Tech.
Bromodomain TR-FRET Competition Binding Assay
IC50
>10±n/a nM
Citation
 Ruppel, SK; Yang, Z; Lowe, JT; Voigt, JH; Netherton, M Compounds and uses thereof US Patent  US11414416 Publication Date 8/16/2022 
Target
Name:
Bromodomain-containing protein 9 [133-239]
Synonyms:
BRD9 | BRD9_HUMAN | Bromodomain-containing protein 9 (BRD9)(133-239)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12383.34
Organism:
Homo sapiens (Human)
Description:
aa 133-239
Residue:
107
Sequence:
PAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSK
  
Inhibitor
Name:
BDBM565296
Synonyms:
3-[([[2,6-dimethoxy-4-(2-methyl-1-oxo-2,7-naphthyridin-4-yl)phenyl]methyl](methyl)amino)methyl]-N-[2-[2-(2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy)ethoxy]ethyl]bicyclo[1.1.1]pentane-1-carboxamide | US11414416, Compound D55 | US11560381, Compound D55
Type:
Small organic molecule
Emp. Form.:
C45H51N7O10
Mol. Mass.:
849.9273
SMILES:
COc1cc(cc(OC)c1CN(C)CC12CC(C1)(C2)C(=O)NCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)-c1cn(C)c(=O)c2cnccc12
Structure:
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