Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 9 [133-239]
Ligand
BDBM565302
Substrate
n/a
Meas. Tech.
Bromodomain TR-FRET Competition Binding Assay
IC50
<10±n/a nM
Citation
 Ruppel, SK; Yang, Z; Lowe, JT; Voigt, JH; Netherton, M Compounds and uses thereof US Patent  US11414416 Publication Date 8/16/2022 
Target
Name:
Bromodomain-containing protein 9 [133-239]
Synonyms:
BRD9 | BRD9_HUMAN | Bromodomain-containing protein 9 (BRD9)(133-239)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12383.34
Organism:
Homo sapiens (Human)
Description:
aa 133-239
Residue:
107
Sequence:
PAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSK
  
Inhibitor
Name:
BDBM565302
Synonyms:
5-(2-(4-(((1-(2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)azetidin-3-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | US11414416, Compound D61 | US11560381, Compound D61
Type:
Small organic molecule
Emp. Form.:
C39H38N8O9
Mol. Mass.:
762.7672
SMILES:
COc1cc(cc(OC)c1CN1CC(C1)OCc1cn(CCOc2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)nn1)-c1cn(C)c(=O)c2cnccc12
Structure:
Search PDB for entries with ligand similarity: