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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM565420
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
5500±n/a nM
Citation
 Palmer, BD; Ching, L Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy US Patent  US11414428 Publication Date 8/16/2022 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM565420
Synonyms:
US11414428, Compound 4
Type:
Small organic molecule
Emp. Form.:
C15H12ClN3O3
Mol. Mass.:
317.727
SMILES:
Cc1nc2onc(NC(=O)Oc3ccccc3)c2c(C)c1Cl
Structure:
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