Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [179-426]
Ligand
BDBM107710
Substrate
n/a
Meas. Tech.
EGLN-1 Activity Assay
IC50
2500±n/a nM
Citation
 Kawamoto, RM; Wu, S; Evdokimov, AG; Greis, KD; Boyer, AS; Warshakoon, NC Prolyl hydroxylase inhibitors and methods of use US Patent  US11426393 Publication Date 8/30/2022 
Target
Name:
Egl nine homolog 1 [179-426]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2)
Type:
n/a
Mol. Mass.:
27759.84
Organism:
Homo sapiens (Human)
Description:
EGLN-1-179/426
Residue:
248
Sequence:
LRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM107710
Synonyms:
US11426393, Compound Table XV.16 | US8598210, Table XV, 16 | US8722895, 16: {[5-(2-Methyl-5-chlorophenyl)-3- hydroxypyridine-2-carbonyl]amino}-acetic acid | US9598370, Example 00141 | USRE47437, Example {[5-(2-Methyl-5-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-aceticacid
Type:
Small organic molecule
Emp. Form.:
C15H13ClN2O4
Mol. Mass.:
320.728
SMILES:
Cc1ccc(Cl)cc1-c1cnc(C(=O)NCC(O)=O)c(O)c1
Structure:
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