Target
N-glycosylase/DNA lyase
Ligand
BDBM570789
Substrate
n/a
Meas. Tech.
OGG1 Inhibitor Assays
IC50
1700±n/a nM
Citation
 Kool, ETTahara, Y Substituted 1,2,3,4-tetrahydroquinolines as inhibitors of repair enzyme 8-oxoguanine deoxyribonucleic acid glycosylase activity US Patent  US11440887 Publication Date 9/13/2022 
Target
Name:
N-glycosylase/DNA lyase
Synonyms:
8-Oxoguanine DNA glycosylase-1 (OGG1) | MMH | MUTM | OGG1 | OGG1_HUMAN | OGH1
Type:
Protein
Mol. Mass.:
38794.33
Organism:
Homo sapiens (Human)
Description:
O15527
Residue:
345
Sequence:
MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
  
Inhibitor
Name:
BDBM570789
Synonyms:
US11440887, Compound 1
Type:
Small organic molecule
Emp. Form.:
C19H22N2O4S
Mol. Mass.:
374.454
SMILES:
CCOc1ccc(cc1)S(=O)(=O)Nc1ccc2CCCN(C(C)=O)c2c1
Structure:
Search PDB for entries with ligand similarity: