Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM571865
Substrate
n/a
Meas. Tech.
Binding Inhibition for Dopamine D3 Receptor
Ki
0.110±n/a nM
Citation
 Ichihashi, Y; Inagaki, M; Masuda, K Cyclic compound having dopamine D3 receptor antagonistic effect US Patent  US11447484 Publication Date 9/20/2022 
Target
Name:
D(3) dopamine receptor
Synonyms:
DRD3 | DRD3_HUMAN | Dopamine D3 receptor
Type:
PROTEIN
Mol. Mass.:
44213.40
Organism:
Homo sapiens
Description:
ChEMBL_105671
Residue:
400
Sequence:
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM571865
Synonyms:
US11447484, Compound I-022
Type:
Small organic molecule
Emp. Form.:
C27H35F2N5O2
Mol. Mass.:
499.5959
SMILES:
Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCC(CC2)c2nocc2C(C)(F)F)CC1 |r,wU:16.18,wD:13.14,(10.89,-.1,;9.99,1.15,;8.45,1.15,;7.97,2.61,;6.56,3.24,;6.4,4.77,;7.65,5.67,;9.06,5.05,;9.22,3.52,;10.46,2.61,;5.32,2.33,;5.48,.8,;3.91,2.96,;2.66,2.05,;1.26,2.68,;.01,1.77,;.17,.24,;-1.07,-.66,;-2.48,-.04,;-3.73,-.94,;-3.56,-2.47,;-4.81,-3.38,;-6.22,-2.75,;-6.38,-1.22,;-5.13,-.32,;-7.46,-3.66,;-7.46,-5.2,;-8.93,-5.67,;-9.83,-4.43,;-8.93,-3.18,;-9.4,-1.72,;-10.89,-1.32,;-7.92,-1.32,;-9.01,-.23,;1.58,-.38,;2.83,.52,)|
Structure:
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