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Target
Stimulator of interferon genes protein [1-379,R71H,G230A,H232R,R293Q]
Ligand
BDBM573949
Substrate
n/a
Meas. Tech.
3H-cGAMP Filtration Binding Assay (HAQ STING)
EC50
253±n/a nM
Citation
 Altman, MD; Andresen, B; Chang, W; Cumming, JN; Otte, RD; Trotter, BW Cyclic di-nucleotide compounds as sting agonists US Patent  US11453697 Publication Date 9/27/2022 
Target
Name:
Stimulator of interferon genes protein [1-379,R71H,G230A,H232R,R293Q]
Synonyms:
ERIS | HAQ STING(1-379) (R71H, G230A, H232R, R293Q) | MITA | STING | STING1 | STING_HUMAN | Stimulator of interferon genes protein (1-379) (R71H, G230A, H232R, R293Q) | Stimulator of interferon genes protein [R71H,G230A,H232R,R293Q] | TMEM173
Type:
Protein
Mol. Mass.:
42180.60
Organism:
Human
Description:
HAQ STING(1-379) (R71H, G230A, H232R, R293Q)
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELHHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTADRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCQTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM573949
Synonyms:
2-amino-9- [(5R,7R,8S,12aR,14R,15R,15aS,18R)-14-(6- amino-9H-purin-9-yl)-18-fluoro-2,10-dioxido- 2,10-disulfanylhexahydro-14H-15,12a- (epoxymethano)-5,8-methanofuro[3,2-l] [1,3,6,9,11,2,10]pentaoxadiphosphacyclotetra- decin-7(12H)-yl]-1,9-dihydro-6H-purin-6-one (Diastereomer 1) | US11453697, Example 134 | US11453697, Example 135 | US11453697, Example 136 | US11453697, Example 137
Type:
Small organic molecule
Emp. Form.:
C21H23FN10O10P2S2
Mol. Mass.:
720.544
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(S)(=O)O[C@H]3[C@H]4OCC3(COP(S)(=O)O[C@@H]1[C@@H]2F)O[C@H]4n1cnc2c(N)ncnc12 |r|
Structure:
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