Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 11 [E76K]
Ligand
BDBM384191
Substrate
n/a
Meas. Tech.
PTPN11 Enzymatic Assay
IC50
43.0±n/a nM
Citation
 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C Heterocyclic inhibitors of PTPN11 US Patent  US11466017 Publication Date 10/11/2022 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11 [E76K]
Synonyms:
PTN11_HUMAN | PTP2C | PTPN11 | Protein-tyrosine phosphatase 1D | SHPTP2 | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)(E76K)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
68019.14
Organism:
Homo sapiens (Human)
Description:
Q06124[E76K]
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM384191
Synonyms:
(R)-8-(3-(3-Chloro-2-(methylamino)pyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine | US10280171, Example 111 | US10851110, Example 111 | US11466017, Example 111
Type:
Small organic molecule
Emp. Form.:
C20H25ClN8
Mol. Mass.:
412.919
SMILES:
CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl |r|
Structure:
Search PDB for entries with ligand similarity: