Reaction Details Report a problem with these data
Target
Ceramide glucosyltransferase
Ligand
BDBM576435
Substrate
n/a
Meas. Tech.
UDP-Glo Glucosylceramide Synthase Biochemical Assay
EC50
0.91±n/a nM
Citation
 J., BM; E., FM; Marie, LH; J., MJ; J., RA; M., SK; J., SS MODIFIED ISOINDOLINONES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG
Type:
PROTEIN
Mol. Mass.:
44859.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435474
Residue:
394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM576435
Synonyms:
WO2022115301, Example 21
Type:
Small organic molecule
Emp. Form.:
C23H23F4NO3
Mol. Mass.:
437.4272
SMILES:
CC(C)(O)C(C1CC1)N1Cc2ccc(F)c(c2C1=O)-c1ccccc1OCC(F)(F)F |(2.99,-.96,;3.76,-2.29,;5.3,-2.29,;4.53,-3.63,;2.99,-3.63,;3.76,-4.96,;3.76,-6.5,;5.1,-5.73,;1.45,-3.63,;.55,-4.87,;-.92,-4.4,;-2.25,-5.17,;-3.58,-4.4,;-3.58,-2.85,;-4.92,-2.08,;-2.25,-2.08,;-.92,-2.85,;.55,-2.38,;1.02,-.91,;-2.25,-.54,;-.92,.23,;-.92,1.77,;-2.25,2.54,;-3.58,1.77,;-3.58,.23,;-4.92,-.54,;-6.25,.23,;-7.58,-.54,;-8.92,.23,;-7.58,-2.08,;-6.25,-1.31,)|
Structure:
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