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Target
Ceramide glucosyltransferase
Ligand
BDBM576437
Substrate
n/a
Meas. Tech.
UDP-Glo Glucosylceramide Synthase Biochemical Assay
EC50
0.41±n/a nM
Citation
 J., BM; E., FM; Marie, LH; J., MJ; J., RA; M., SK; J., SS MODIFIED ISOINDOLINONES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG
Type:
PROTEIN
Mol. Mass.:
44859.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435474
Residue:
394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM576437
Synonyms:
WO2022115301, Example 23
Type:
Small organic molecule
Emp. Form.:
C23H23F4NO3
Mol. Mass.:
437.4272
SMILES:
CC(C)(O)C(C1CC1)N1Cc2cc(F)cc(c2C1=O)-c1ccccc1OCC(F)(F)F
Structure:
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