Reaction Details Report a problem with these data
Target
Exotoxin A
Ligand
BDBM576459
Substrate
n/a
Meas. Tech.
Activity Assays
EC50
160±70 nM
Citation
 Futerman, AH; Joseph, T; Shaw, WA; Burgess, SW; Li, S Sphingosine analogs and use thereof against bacterial lung infections US Patent  US11471430 Publication Date 10/18/2022 
Target
Name:
Exotoxin A
Synonyms:
NAD(+)--diphthamide ADP-ribosyltransferase | PE | Pseudomonas exotoxin | TOXA_PSEAE | eta
Type:
Protein
Mol. Mass.:
69271.62
Organism:
n/a
Description:
P11439
Residue:
638
Sequence:
MHLTPHWIPLVASLGLLAGGSFASAAEEAFDLWNECAKACVLDLKDGVRSSRMSVDPAIADTNGQGVLHYSMVLEGGNDALKLAIDNALSITSDGLTIRLEGGVEPNKPVRYSYTRQARGSWSLNWLVPIGHEKPSNIKVFIHELNAGNQLSHMSPIYTIEMGDELLAKLARDATFFVRAHESNEMQPTLAISHAGVSVVMAQAQPRREKRWSEWASGKVLCLLDPLDGVYNYLAQQRCNLDDTWEGKIYRVLAGNPAKHDLDIKPTVISHRLHFPEGGSLAALTAHQACHLPLETFTRHRQPRGWEQLEQCGYPVQRLVALYLAARLSWNQVDQVIRNALASPGSGGDLGEAIREQPEQARLALTLAAAESERFVRQGTGNDEAGAASADVVSLTCPVAAGECAGPADSGDALLERNYPTGAEFLGDGGDISFSTRGTQNWTVERLLQAHRQLEERGYVFVGYHGTFLEAAQSIVFGGVRARSQDLDAIWRGFYIAGDPALAYGYAQDQEPDARGRIRNGALLRVYVPRSSLPGFYRTGLTLAAPEAAGEVERLIGHPLPLRLDAITGPEEEGGRLETILGWPLAERTVVIPSAIPTDPRNVGGDLDPSSIPDKEQAISALPDYASQPGKPPREDLK
 
Inhibitor
Name:
BDBM576459
Synonyms:
US11471430, Compound 792212
Type:
Small organic molecule
Emp. Form.:
C22H39N3O
Mol. Mass.:
361.5646
SMILES:
CCCCCCCCCCCCc1ccc(NC(=O)[C@@H](N)CCN)cc1 |r|
Structure:
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