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Target
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) [50-672]
Ligand
BDBM577079
Substrate
n/a
IC50
36.3±n/a nM
Citation
 Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent  US11472805 Publication Date 10/18/2022 
Target
Name:
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) [50-672]
Synonyms:
DPDE3 | PDE4D | PDE4D_HUMAN
Type:
n/a
Mol. Mass.:
70900.69
Organism:
Homo sapiens (Human)
Description:
Q08499-2[50-672]
Residue:
623
Sequence:
QRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPD
  
Inhibitor
Name:
BDBM577079
Synonyms:
4-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2′,3′:4,5]pyrrolo[1,2-a]pyrazin-10-yl)-2-fluorobenzonitrile | US11472805, Example 4
Type:
Small organic molecule
Emp. Form.:
C20H15FN4O
Mol. Mass.:
346.3577
SMILES:
Fc1cc(ccc1C#N)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
Structure:
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