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Target
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) [50-672]
Ligand
BDBM577176
Substrate
n/a
IC50
42.8±n/a nM
Citation
 Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent  US11472805 Publication Date 10/18/2022 
Target
Name:
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) [50-672]
Synonyms:
DPDE3 | PDE4D | PDE4D_HUMAN
Type:
n/a
Mol. Mass.:
70900.69
Organism:
Homo sapiens (Human)
Description:
Q08499-2[50-672]
Residue:
623
Sequence:
QRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPD
  
Inhibitor
Name:
BDBM577176
Synonyms:
10-(4-Chlorophenyl)-N-ethyl-9-oxo-6,7-dihydropyrido[2',3':4,5]pyrrolo[1,2-a]pyrazine-8(9H)-carboxamide | US11472805, Example 80
Type:
Small organic molecule
Emp. Form.:
C19H17ClN4O2
Mol. Mass.:
368.817
SMILES:
CCNC(=O)N1CCn2c(c(-c3ccc(Cl)cc3)c3ncccc23)C1=O
Structure:
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