Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [139-379, H232R]
Ligand
BDBM577469
Substrate
n/a
Meas. Tech.
STING SPA Binding Assay
IC50
>100000±n/a nM
Citation
 Bignan, G; Connolly, P; Edwards, JP; Emanuel, S; Laquerre, S; Lu, T; Richter, M; Beigelman, L; Thatikonda, SK; Wang, G; Zhong, M Cyclic dinucleotides as sting agonists US Patent  US11472830 Publication Date 10/18/2022 
Target
Name:
Stimulator of interferon genes protein [140-379]
Synonyms:
ERIS | MITA | STING | STING1 | STING_HUMAN | Stimulator of interferon genes protein STING (140-379) | TMEM173
Type:
Enzyme Catalytic Domain
Mol. Mass.:
26958.07
Organism:
Homo sapiens (Human)
Description:
aa 140-379
Residue:
240
Sequence:
APAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM577469
Synonyms:
US11472830, Cpd No. 1
Type:
Small organic molecule
Emp. Form.:
C21H26N10O13P2
Mol. Mass.:
688.4379
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)C1OC2COP(O)(=O)OC3C(COP(O)(=O)OC1C2O)OC(C3CO)n1cnc2c(N)ncnc12
Structure:
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