Reaction Details Report a problem with these data
Target
Rho-associated protein kinase 1 [1-535]
Ligand
BDBM578434
Substrate
n/a
Meas. Tech.
Z-lyte assay
IC50
258±n/a nM
Citation
 Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R; Zhang, J Inhibitors of Rho associated coiled-coil containing protein kinase US Patent  US11479533 Publication Date 10/25/2022 
Target
Name:
Rho-associated protein kinase 1 [1-535]
Synonyms:
ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1)
Type:
Enzyme
Mol. Mass.:
62220.48
Organism:
Homo sapiens (Human)
Description:
aa 1-535
Residue:
535
Sequence:
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
  
Inhibitor
Name:
BDBM578434
Synonyms:
(S)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethylamino)ethyl)amino)-2-(3-methoxyphenyl)acetamide | US11479533, Example 60
Type:
Small organic molecule
Emp. Form.:
C22H27N5O2
Mol. Mass.:
393.4821
SMILES:
COc1cccc(c1)[C@H](NCCN(C)C)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 |r|
Structure:
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