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Target
Rho-associated protein kinase 1 [1-535]
Ligand
BDBM578444
Substrate
n/a
Meas. Tech.
Z-lyte assay
IC50
85.0±n/a nM
Citation
 Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R; Zhang, J Inhibitors of Rho associated coiled-coil containing protein kinase US Patent  US11479533 Publication Date 10/25/2022 
Target
Name:
Rho-associated protein kinase 1 [1-535]
Synonyms:
ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1)
Type:
Enzyme
Mol. Mass.:
62220.48
Organism:
Homo sapiens (Human)
Description:
aa 1-535
Residue:
535
Sequence:
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
  
Inhibitor
Name:
BDBM578444
Synonyms:
N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methyl-1H-indazol-6-yl)-2-(methylamino)acetamide | US11479533, Example 33
Type:
Small organic molecule
Emp. Form.:
C20H20N6O
Mol. Mass.:
360.4124
SMILES:
CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccc2c(C)n[nH]c2c1
Structure:
Search PDB for entries with ligand similarity: