Reaction Details Report a problem with these data
Target
Rho-associated protein kinase 2 [1-552]
Ligand
BDBM578471
Substrate
n/a
Meas. Tech.
Z-lyte assay
IC50
8.10±n/a nM
Citation
 Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R; Zhang, J Inhibitors of Rho associated coiled-coil containing protein kinase US Patent  US11479533 Publication Date 10/25/2022 
Target
Name:
Rho-associated protein kinase 2 [1-552]
Synonyms:
KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2)
Type:
Enzyme
Mol. Mass.:
63353.50
Organism:
Homo sapiens (Human)
Description:
aa 1-552
Residue:
552
Sequence:
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQI
  
Inhibitor
Name:
BDBM578471
Synonyms:
N-(2-(2-(dimethylamino)ethoxy)-5-fluoro-4-(1H-pyrazol-4-yl)phenyl)-2-((2-methoxyethyl)(methyl)amino)-2-(3-methoxyphenyl)acetamide | US11479533, Example 51
Type:
Small organic molecule
Emp. Form.:
C26H34FN5O4
Mol. Mass.:
499.5777
SMILES:
COCCN(C)C(C(=O)Nc1cc(F)c(cc1OCCN(C)C)-c1cn[nH]c1)c1cccc(OC)c1
Structure:
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