Reaction Details Report a problem with these data
Target
2-acylglycerol O-acyltransferase 2
Ligand
BDBM400246
Substrate
n/a
Meas. Tech.
MGAT LCMS Assay
IC50
5.00±n/a nM
Citation
 Ahmad, S Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors US Patent  US11479538 Publication Date 10/25/2022 
Target
Name:
2-acylglycerol O-acyltransferase 2
Synonyms:
2-acylglycerol O-acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 (MOGAT2) | DC5 | DGAT2L5 | Diacylglycerol O-acyltransferase candidate 5 | Diacylglycerol acyltransferase 2-like protein 5 | MGAT2 | MOGAT2 | MOGT2_HUMAN | Monoacylglycerol Acyltransferase 2 (MGAT2) | Monoacylglycerol O-acyltransferase 2 | hDC5 | hMGAT2
Type:
Enzyme
Mol. Mass.:
38210.80
Organism:
Homo sapiens (Human)
Description:
Q3SYC2
Residue:
334
Sequence:
MVEFAPLFMPWERRLQTLAVLQFVFSFLALAEICTVGFIALLFTRFWLLTVLYAAWWYLDRDKPRQGGRHIQAIRCWTIWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESAAHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSGSWLRYIQNRLQKIMGISLPLFHGRGVFQYSFGLIPYRRPITTVVGKPIEVQKTLHPSEEEVNQLHQRYIKELCNLFEAHKLKFNIPADQHLEFC
  
Inhibitor
Name:
BDBM400246
Synonyms:
US10329273, Example 17 | US11479538, Example 17
Type:
Small organic molecule
Emp. Form.:
C27H29F6N7O2
Mol. Mass.:
597.5553
SMILES:
FC(F)(F)CCCCCCn1cc(cn1)[C@@]1(CC(=C(C(=O)N1)n1nn[nH]c1=O)c1ccc2CCCCc2c1)C(F)(F)F |r,c:18|
Structure:
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