Reaction Details Report a problem with these data
Target
2-acylglycerol O-acyltransferase 2
Ligand
BDBM50518069
Substrate
n/a
Meas. Tech.
MGAT LCMS Assay
IC50
2.00±n/a nM
Citation
 Ahmad, S Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors US Patent  US11479538 Publication Date 10/25/2022 
Target
Name:
2-acylglycerol O-acyltransferase 2
Synonyms:
2-acylglycerol O-acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 (MOGAT2) | DC5 | DGAT2L5 | Diacylglycerol O-acyltransferase candidate 5 | Diacylglycerol acyltransferase 2-like protein 5 | MGAT2 | MOGAT2 | MOGT2_HUMAN | Monoacylglycerol Acyltransferase 2 (MGAT2) | Monoacylglycerol O-acyltransferase 2 | hDC5 | hMGAT2
Type:
Enzyme
Mol. Mass.:
38210.80
Organism:
Homo sapiens (Human)
Description:
Q3SYC2
Residue:
334
Sequence:
MVEFAPLFMPWERRLQTLAVLQFVFSFLALAEICTVGFIALLFTRFWLLTVLYAAWWYLDRDKPRQGGRHIQAIRCWTIWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESAAHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSGSWLRYIQNRLQKIMGISLPLFHGRGVFQYSFGLIPYRRPITTVVGKPIEVQKTLHPSEEEVNQLHQRYIKELCNLFEAHKLKFNIPADQHLEFC
  
Inhibitor
Name:
BDBM50518069
Synonyms:
CHEMBL4542050 | US11479538, Example 22
Type:
Small organic molecule
Emp. Form.:
C23H19F7N6O3S
Mol. Mass.:
592.489
SMILES:
Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ncc(s2)C2CC2)=C(C(=O)N1)n1nn[nH]c1=O)C(F)(F)F |r,c:28|
Structure:
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