Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [58-164]
Ligand
BDBM318457
Substrate
n/a
Meas. Tech.
BRD4 AlphaScreen Assay
IC50
<100±n/a nM
Citation
 Combs, AP; Sparks, RB; Maduskuie, Jr., TP; Rodgers, JD Tricyclic heterocycles as BET protein inhibitors US Patent  US11498926 Publication Date 11/15/2022 
Target
Name:
Bromodomain-containing protein 4 [58-164]
Synonyms:
BRD4 | BRD4-1 | BRD4_HUMAN | Bromodomain-containing protein 4 (BD1, aa 58-164) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12525.99
Organism:
Homo sapiens (Human)
Description:
O60885[58-164]
Residue:
104
Sequence:
NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL
  
Inhibitor
Name:
BDBM318457
Synonyms:
7-(3,5-Dimethylisoxazol-4-yl)-1-methyl-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one | US10464947, Example 2 | US11498926, Example 2 | US9624241, Example 2
Type:
Small organic molecule
Emp. Form.:
C21H19N3O3
Mol. Mass.:
361.3939
SMILES:
Cc1noc(C)c1-c1ccc2n(C)c(=O)n3C(COc1c23)c1ccccc1 |(-.82,-6.16,;-2.15,-5.39,;-3.61,-5.87,;-4.52,-4.62,;-3.61,-3.37,;-4.38,-2.04,;-2.15,-3.85,;-.82,-3.08,;.52,-3.85,;1.85,-3.08,;1.85,-1.54,;3.19,-.77,;4.52,-1.54,;2.06,.77,;2.83,2.1,;.52,.77,;-.82,1.54,;-2.15,.77,;-2.15,-.77,;-.82,-1.54,;.52,-.77,;-.82,3.08,;.52,3.85,;.52,5.39,;-.82,6.16,;-2.15,5.39,;-2.15,3.85,)|
Structure:
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