Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [58-164]
Ligand
BDBM318483
Substrate
n/a
Meas. Tech.
BRD4 AlphaScreen Assay
IC50
<100±n/a nM
Citation
 Combs, AP; Sparks, RB; Maduskuie, Jr., TP; Rodgers, JD Tricyclic heterocycles as BET protein inhibitors US Patent  US11498926 Publication Date 11/15/2022 
Target
Name:
Bromodomain-containing protein 4 [58-164]
Synonyms:
BRD4 | BRD4-1 | BRD4_HUMAN | Bromodomain-containing protein 4 (BD1, aa 58-164) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12525.99
Organism:
Homo sapiens (Human)
Description:
O60885[58-164]
Residue:
104
Sequence:
NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL
  
Inhibitor
Name:
BDBM318483
Synonyms:
2-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]amino}ethanol | US10464947, Example 29 | US11498926, Example 29 | US9624241, Example 29
Type:
Small organic molecule
Emp. Form.:
C22H22N4O3
Mol. Mass.:
390.4351
SMILES:
Cc1noc(C)c1-c1ccc2nc(NCCO)n3C(COc1c23)c1ccccc1 |(-1.9,-6.16,;-3.23,-5.39,;-4.69,-5.87,;-5.6,-4.62,;-4.69,-3.37,;-5.46,-2.04,;-3.23,-3.85,;-1.9,-3.08,;-.56,-3.85,;.77,-3.08,;.77,-1.54,;2.11,-.77,;.98,.77,;1.75,2.1,;3.29,2.1,;4.06,3.44,;5.6,3.44,;-.56,.77,;-1.9,1.54,;-3.23,.77,;-3.23,-.77,;-1.9,-1.54,;-.56,-.77,;-1.9,3.08,;-.56,3.85,;-.56,5.39,;-1.9,6.16,;-3.23,5.39,;-3.23,3.85,)|
Structure:
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