Reaction Details Report a problem with these data
Target
Histone acetyltransferase KAT8
Ligand
BDBM580731
Substrate
n/a
Meas. Tech.
Kat8 Assay
Ki
1440±n/a nM
Citation
 Bozikis, YE; Camerino, MA; Kung, P; Stupple, PA; Sutton, SC Benzisoxazole sulfonamide derivatives US Patent  US11492346 Publication Date 11/8/2022 
Target
Name:
Histone acetyltransferase KAT8
Synonyms:
KAT8 | KAT8_HUMAN | Lysine acetyltransferase 8 | MOF | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 | MYST-1 | MYST1 | hMOF
Type:
PROTEIN
Mol. Mass.:
52413.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_796800
Residue:
458
Sequence:
MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
  
Inhibitor
Name:
BDBM580731
Synonyms:
US11492346, Example 71
Type:
Small organic molecule
Emp. Form.:
C19H17ClN4O5S
Mol. Mass.:
448.88
SMILES:
COc1cc(Cl)ccc1S(=O)(=O)Nc1noc2cc(Cn3cccn3)cc(OC)c12
Structure:
Search PDB for entries with ligand similarity: