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Target
2-Hydroxyacid oxidase 1
Ligand
BDBM581151
Substrate
n/a
Meas. Tech.
In-Vitro Human Glycolate Oxidase (hGOX) Assay
IC50
2.00±n/a nM
Citation
 Kabakibi, A; Kahraman, M; Clare, M; Leedom, T Compounds and methods for treating oxalate-related diseases US Patent  US11504367 Publication Date 11/22/2022 
Target
Name:
2-Hydroxyacid oxidase 1
Synonyms:
GOX1 | HAO1 | HAOX1_HUMAN | Hydroxyacid oxidase 1
Type:
PROTEIN
Mol. Mass.:
40927.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_71275
Residue:
370
Sequence:
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
  
Inhibitor
Name:
BDBM581151
Synonyms:
5-(4-((1-methyl-6-oxo-1,6- dihydropyridin-3- yl)ethynyl)phenoxy)-1H-1,2,3- triazole-4-carboxylic acid | US11504367, Example 208
Type:
Small organic molecule
Emp. Form.:
C17H12N4O4
Mol. Mass.:
336.3016
SMILES:
Cn1cc(ccc1=O)C#Cc1ccc(Oc2[nH]nnc2C(O)=O)cc1
Structure:
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