Target
2-Hydroxyacid oxidase 1
Ligand
BDBM581173
Substrate
n/a
Meas. Tech.
In-Vitro Human Glycolate Oxidase (hGOX) Assay
IC50
2.00±n/a nM
Citation
 Kabakibi, AKahraman, MClare, MLeedom, T Compounds and methods for treating oxalate-related diseases US Patent  US11504367 Publication Date 11/22/2022 
Target
Name:
2-Hydroxyacid oxidase 1
Synonyms:
GOX1 | HAO1 | HAOX1_HUMAN | Hydroxyacid oxidase 1
Type:
PROTEIN
Mol. Mass.:
40927.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_71275
Residue:
370
Sequence:
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
  
Inhibitor
Name:
BDBM581173
Synonyms:
5-(4-((3- cyanophenyl)ethynyl)-3- fluorophenoxy)-1H-1,2,3- triazole-4-carboxylic acid | US11504367, Example 271
Type:
Small organic molecule
Emp. Form.:
C18H9FN4O3
Mol. Mass.:
348.2875
SMILES:
OC(=O)c1nn[nH]c1Oc1ccc(F)c(c1)C#Cc1cccc(c1)C#N
Structure:
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