Reaction Details Report a problem with these data
Target
2-Hydroxyacid oxidase 1
Ligand
BDBM581193
Substrate
n/a
Meas. Tech.
In-Vitro Human Glycolate Oxidase (hGOX) Assay
IC50
0.400±n/a nM
Citation
 Kabakibi, A; Kahraman, M; Clare, M; Leedom, T Compounds and methods for treating oxalate-related diseases US Patent  US11504367 Publication Date 11/22/2022 
Target
Name:
2-Hydroxyacid oxidase 1
Synonyms:
GOX1 | HAO1 | HAOX1_HUMAN | Hydroxyacid oxidase 1
Type:
PROTEIN
Mol. Mass.:
40927.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_71275
Residue:
370
Sequence:
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
  
Inhibitor
Name:
BDBM581193
Synonyms:
5-(4-(2-(4-chlorophenyl) ethynyl)phenoxy)-1H-1,2,3- triazole-4-carboxylic acid | US11504367, Example 290
Type:
Small organic molecule
Emp. Form.:
C17H10ClN3O3
Mol. Mass.:
339.733
SMILES:
OC(=O)c1nn[nH]c1Oc1ccc(cc1)C#Cc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: