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Target
2-Hydroxyacid oxidase 1
Ligand
BDBM581220
Substrate
n/a
Meas. Tech.
In-Vitro Human Glycolate Oxidase (hGOX) Assay
IC50
2.00±n/a nM
Citation
 Kabakibi, A; Kahraman, M; Clare, M; Leedom, T Compounds and methods for treating oxalate-related diseases US Patent  US11504367 Publication Date 11/22/2022 
Target
Name:
2-Hydroxyacid oxidase 1
Synonyms:
GOX1 | HAO1 | HAOX1_HUMAN | Hydroxyacid oxidase 1
Type:
PROTEIN
Mol. Mass.:
40927.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_71275
Residue:
370
Sequence:
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
  
Inhibitor
Name:
BDBM581220
Synonyms:
5-(4-(2-(1-methyl-1H-indazol- 5-yl)ethynyl)phenoxy)-1H- 1,2,3-triazole-4-carboxylic acid | US11504367, Example 316
Type:
Small organic molecule
Emp. Form.:
C19H13N5O3
Mol. Mass.:
359.3382
SMILES:
Cn1ncc2cc(ccc12)C#Cc1ccc(Oc2[nH]nnc2C(O)=O)cc1
Structure:
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