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Target
Protein-tyrosine kinase 6
Ligand
BDBM581780
Substrate
n/a
Meas. Tech.
Brk Inhibitory Activity Assay
IC50
5.40±n/a nM
Citation
 Yamamoto, S; Tokura, H; Kurono, M; Nomura, Y; Hotta, S BRK inhibitory compound US Patent  US11512087 Publication Date 11/29/2022 
Target
Name:
Protein-tyrosine kinase 6
Synonyms:
BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:
Tyrosine-protein kinase
Mol. Mass.:
51839.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
  
Inhibitor
Name:
BDBM581780
Synonyms:
US11512087, Example 2
Type:
Small organic molecule
Emp. Form.:
C20H21FN10
Mol. Mass.:
420.4461
SMILES:
CC(C)n1nc(-c2ccc(F)c3[nH]ncc23)c2c(N)nc(Nc3cn(C)nc3C)nc12
Structure:
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