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Target
Protein-tyrosine kinase 6
Ligand
BDBM581837
Substrate
n/a
Meas. Tech.
Brk Inhibitory Activity Assay
IC50
3.40±n/a nM
Citation
 Yamamoto, S; Tokura, H; Kurono, M; Nomura, Y; Hotta, S BRK inhibitory compound US Patent  US11512087 Publication Date 11/29/2022 
Target
Name:
Protein-tyrosine kinase 6
Synonyms:
BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:
Tyrosine-protein kinase
Mol. Mass.:
51839.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
  
Inhibitor
Name:
BDBM581837
Synonyms:
US11512087, Example 25
Type:
Small organic molecule
Emp. Form.:
C24H25FN6O2
Mol. Mass.:
448.4927
SMILES:
CC(C)c1cc(-c2cccc(O)c2)c2c(N)nc(Nc3ccc(cc3F)C(=O)N(C)C)nn12
Structure:
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