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Target
Cation-dependent mannose-6-phosphate receptor
Ligand
BDBM582016
Substrate
n/a
Meas. Tech.
General M6PR Binding Assay
IC50
300±n/a nM
Citation
 Bradley, BB; Thomas, EJ; K., PG; G., LJ; D., TE M6PR CELL SURFACE RECEPTOR BINDING COMPOUNDS AND CONJUGATES WIPO 0:0 (2023) [PubMed] 
Target
Name:
Cation-dependent mannose-6-phosphate receptor
Synonyms:
M6PR | MPR46 | MPRD | MPRD_HUMAN
Type:
PROTEIN
Mol. Mass.:
30989.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_492874
Residue:
277
Sequence:
MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
  
Inhibitor
Name:
BDBM582016
Synonyms:
WO2023288015, Compound Table12B.769
Type:
Small organic molecule
Emp. Form.:
C63H101N13O26P2
Mol. Mass.:
1518.4951
SMILES:
CC(=O)NN(CCCCn1cc(CCCCNC(=O)Nc2ccc(O[C@H]3O[C@H](CCP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]3O)cc2)nn1)[C@@H](CCCCn1cc(CCCCNC(=O)Nc2ccc(O[C@H]3O[C@H](CCP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]3O)cc2)nn1)C(=O)NCCOCCOCCOCCOCCC(O)=O |r|
Structure:
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