Reaction Details Report a problem with these data
Target
Synaptic vesicle glycoprotein 2A
Ligand
BDBM582019
Substrate
n/a
Meas. Tech.
Radioligand Competition Binding Assay
IC50
12.6±n/a nM
Citation
 Huang, Y; Cai, Z; Li, S; Nabulsi, N; Carson, R Radiolabeled pharmaceuticals and methods of making and using same US Patent  US11518754 Publication Date 12/6/2022 
Target
Name:
Synaptic vesicle glycoprotein 2A
Synonyms:
SV2A_RAT | Sv2 | Sv2a | Synaptic vesicle protein 2a
Type:
PROTEIN
Mol. Mass.:
82648.76
Organism:
Rattus norvegicus
Description:
ChEMBL_100153
Residue:
742
Sequence:
MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEEDDDDFPAPADGYYRGEGAQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKDREELAQQYETILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVLSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ
  
Inhibitor
Name:
BDBM582019
Synonyms:
US11518754, Compound (R)-4
Type:
Small organic molecule
Emp. Form.:
C17H16F2N2O
Mol. Mass.:
302.3185
SMILES:
Cc1cnccc1CN1C[C@H](CC1=O)c1ccc(F)c(F)c1 |r|
Structure:
Search PDB for entries with ligand similarity: