Reaction Details Report a problem with these data
Target
Sal-like protein 4
Ligand
BDBM585374
Substrate
n/a
Meas. Tech.
TBD
IC50
619±n/a nM
Citation
 Qi, J; Varca, A; Chai, L Small molecule inhibition of transcription factor SALL4 and uses thereof US Patent  US11530209 Publication Date 12/20/2022 
Target
Name:
Sal-like protein 4
Synonyms:
SALL4 | SALL4_HUMAN | ZNF797 | Zinc finger protein 797 | Zinc finger protein SALL4
Type:
Protein
Mol. Mass.:
112246.17
Organism:
Human
Description:
Q9UJQ4
Residue:
1053
Sequence:
MSRRKQAKPQHINSEEDQGEQQPQQQTPEFADAAPAAPAAGELGAPVNHPGNDEVASEDEATVKRLRREETHVCEKCCAEFFSISEFLEHKKNCTKNPPVLIMNDSEGPVPSEDFSGAVLSHQPTSPGSKDCHRENGGSSEDMKEKPDAESVVYLKTETALPPTPQDISYLAKGKVANTNVTLQALRGTKVAVNQRSADALPAPVPGANSIPWVLEQILCLQQQQLQQIQLTEQIRIQVNMWASHALHSSGAGADTLKTLGSHMSQQVSAAVALLSQKAGSQGLSLDALKQAKLPHANIPSATSSLSPGLAPFTLKPDGTRVLPNVMSRLPSALLPQAPGSVLFQSPFSTVALDTSKKGKGKPPNISAVDVKPKDEAALYKHKCKYCSKVFGTDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRHPQVKANPQLFAEFQDKVAAGNGIPYALSVPDPIDEPSLSLDSKPVLVTTSVGLPQNLSSGTNPKDLTGGSLPGDLQPGPSPESEGGPTLPGVGPNYNSPRAGGFQGSGTPEPGSETLKLQQLVENIDKATTDPNECLICHRVLSCQSSLKMHYRTHTGERPFQCKICGRAFSTKGNLKTHLGVHRTNTSIKTQHSCPICQKKFTNAVMLQQHIRMHMGGQIPNTPLPENPCDFTGSEPMTVGENGSTGAICHDDVIESIDVEEVSSQEAPSSSSKVPTPLPSIHSASPTLGFAMMASLDAPGKVGPAPFNLQRQGSRENGSVESDGLTNDSSSLMGDQEYQSRSPDILETTSFQALSPANSQAESIKSKSPDAGSKAESSENSRTEMEGRSSLPSTFIRAPPTYVKVEVPGTFVGPSTLSPGMTPLLAAQPRRQAKQHGCTRCGKNFSSASALQIHERTHTGEKPFVCNICGRAFTTKGNLKVHYMTHGANNNSARRGRKLAIENTMALLGTDGKRVSEIFPKEILAPSVNVDPVVWNQYTSMLNGGLAVKTNEISVIQSGGVPTLPVSLGATSVVNNATVSKMDGSQSGISADVEKPSATDGVPKHQFPHFLEENKIAVS
  
Inhibitor
Name:
BDBM585374
Synonyms:
US11530209, Compound E5
Type:
Small organic molecule
Emp. Form.:
C23H18N4O2
Mol. Mass.:
382.4146
SMILES:
COc1ccc(Nc2c(nc3cnccn23)-c2c(O)ccc3ccccc23)cc1 |(5.34,4.66,;3.83,4.98,;2.8,3.83,;3.28,2.37,;2.25,1.22,;.74,1.54,;-.29,.4,;.19,-1.06,;-.72,-2.31,;.19,-3.56,;1.65,-3.08,;2.98,-3.85,;4.32,-3.08,;4.32,-1.54,;2.98,-.77,;1.65,-1.54,;-2.26,-2.31,;-3.03,-3.64,;-2.26,-4.98,;-4.57,-3.64,;-5.34,-2.31,;-4.57,-.98,;-5.34,.36,;-4.57,1.69,;-3.03,1.69,;-2.26,.36,;-3.03,-.98,;.27,3.01,;1.3,4.15,)|
Structure:
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